This can be easily done if the first letters are latin characters. But this method does not work with non-latin (for example cyrillic) characters. Just press Ctrl+F, enable "Regular Expression" checkbox, and search for
replace with (Replace All)^(.)
". matches newline" checkbox has to be unchecked\u\1
OR
Well, you can install the TextFX plugin and apply Sentense case.
Here you have some tricks (including this one).
http://a4apphack.com/featured/tricks-with-notepad
TextFX is the easiest solution IMHO. After installing the plugin, simply select all relevant text and then navigate to
TextFX > TextFX Characters > Sentence case